The 4C Mortality Score and 4C Deterioration models are risk stratification tools that predict in-hospital mortality or in-hospital clinical deterioration (defined as any requirement of ventilatory support or critical care, or death) for hospitalised COVID-19 patients, produced by the ISARIC4C consortium.
The Scores are intended to be considered only by clinicians to aid their clinical decision-making, however clinicians should ultimately rely on their own clinical judgement in treatment decisions. In compliance with the Medical Devices Regulations 2002, the raw data generating the Scores and look up table to estimate mortality and probability of deterioration are provided for the clinician to review and as such this webpage is not considered to be a medical device.
They are designed to require only parameters that are commonly available at hospital presentation.
Predictors should be measured at the point of hospital presentation for suspected community-acquired cases, or first evaluation for COVID-19 for suspected nosocomial cases.
They are based on a large UK cohort of patients, and should not be adopted for routine clinical use in other settings until they have been appropriately validated for these settings.
For full details, see the paper introducing the 4C Mortality Score, and the paper (preprint) introducing the 4C Deterioration model.
This is an infographic that visualises risk, based on observed mortality and deterioration among hospitalised adult COVID19 patients enrolled to the ISARIC WHO Clinical Characterisation Protocol UK study.
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